Mapping of genetic modifiers of thymic lymphoma development in p53-knockout mice
نویسندگان
چکیده
منابع مشابه
Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas
Homozygous knockout of p53 in mice leads to early mortality from lymphoma, with almost complete penetrance, thus hampering studies of other tumor histotypes related to p53 alterations. To avoid lymphoma development, we crossed p53 knockout mice (BALB-p53 mice) with alymphocytic BALB/c Rag2-/-;Il2rg-/- (RGKO) mice. We compared the tumor spectrum of homozygous (BALB-p53-/-) and heterozygous (BALB...
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15 صفحه اولPrevention of thymic lymphoma development in Atm-/- mice by dexamethasone.
We have reported (M. Yan et al., FASEB J., 15: 1132-1138, 2001) that spontaneous DNA synthesisis markedly increased in the thymocytes from the atrophied thymi of young Atm-/- mice. We, therefore, set out to determine whether this elevated DNA synthesis is responsible for the development of thymic lymphomas in all Atm-/- mice by 4-5 months of age. We show here that in Atm-/- mice: (a) increased ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2003
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1206202